Premium Marble Hash
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When you use cannabis, certain compounds in it, including THC, the psychoactive compound in cannabis, bind to endocannabinoid receptors in various parts of your brain, including the amygdala.
Your amygdala helps regulate your response to fear and related emotions, like anxiety, stress, and — wait for it — paranoia. When you use cannabis that’s rich in THC, your brain suddenly receives more cannabinoids than usual. Research suggests this excess of cannabinoids may overstimulate the amygdala, making you feel fear and anxiety.
This would also explain why products rich in cannabidiol (CBD), a cannabinoid that doesn’t directly bind to endocannabinoid receptors, don’t seem to cause paranoia.
Genetics of Premium Marble Hash
According to an animal study from 2019Trusted Source, cannabis tends to produce positive effects, such as relaxation and decreased anxiety, when it provides more stimulation to the front region of the brain.
Using marijuana with higher THC content may also contribute to paranoia and other negative symptoms.
A 2017 study looking at 42 healthy adults found evidence to suggest that consuming 7.5 milligrams (mg) of THC reduced negative feelings associated with a stressful task. A higher dose of 12.5 mg, on the other hand, had the opposite effect and increased those same negative feelings.
While other factors like tolerance, genetics, and brain chemistry can come into play here, you’re generally more likely to experience paranoia or anxiety when you consume a lot of cannabis at once or use high-THC strains.